The largest meta-analysis so far of Mindfulness-Based Cognitive Therapy (MBCT) for recurrent depression has found that MBCT is an effective treatment option that can help prevent the recurrence of major depression. The study used anonymised individual patient data from nine randomized trials of MBCT. It suggests that for the millions of people who suffer recurrent depression it provides a treatment choice and an alternative or addition to other approaches such as maintenance anti-depressants.
Major depression is a significant public health problem. Without ongoing treatment, as many as four out of five people with depression relapse at some point. MBCT is a group-based psychological treatment that helps people change the way they think and feel about their experiences and learn skills that reduce the likelihood of further episodes of depression. This meta-analysis, included data from trials that compared MBCT to usual care as well as to other active treatments such as maintenance antidepressants – the current mainstay approach to prevention of depressive relapse.
Across the nine trials, 38% of those who received MBCT had a depressive relapse within 60 weeks' follow-up, in contrast to 49% of those who did not receive MBCT. Taking the time to relapse into account, people who received MBCT were 31% less likely to relapse during the 60-week follow-up compared with those who did not receive MBCT.
The inclusion of individual patient data made it possible to demonstrate that a person's age, sex, level of education and the age at which they first became depressed did not significantly influence the effectiveness of MBCT, suggesting that this approach is useful for a broad range of people. Those people who experienced more symptoms of depression when they entered treatment tended to show greater benefits from MBCT compared with other treatments. Clinical trials systematically record the occurrence of adverse events and negative outcomes such as death or hospitalisation for any cause. The study found no evidence of adverse events associated with MBCT when delivered by well-trained teachers in a clinical context.
Four of the trials that contributed to the meta-analysis compared MBCT combined with continuation, tapering, or discontinuation of antidepressants to continued maintenance antidepressant treatment alone. Data from these trials showed that those who received MBCT, and in many cases tapered or discontinued antidepressant medication, were 23% less likely to relapse to major depression than those who continued on antidepressants and did not receive MBCT.
Reflecting on the findings, Richard Byng, Professor of Primary Care, University of Plymouth and one of the co-authors, said: 'While the evidence is from a relatively small number of trials, it is encouraging for patients and clinicians to have another option. There was insufficient data to examine which types of patient or context predict who would benefit most. This, along with varied individual study and wide combined study confidence intervals, means that clinicians need to be cautiously optimistic when tapering off antidepressant medication, and treat each patient as an individual who may or may not benefit from both MBCT and other effective treatments.'
Lead author, Willem Kuyken, Professor of Clinical Psychology at the Oxford Mindfulness Centre said: 'This new evidence for Mindfulness-based Cognitive Therapy, collated from individual patient data across nine randomised trials is very heartening. While MBCT is not a panacea, it does clearly offer those with a substantial history of depression a new approach to learning skills to stay well in the long-term. It offers people a safe and empowering treatment choice alongside other mainstay approaches such as cognitive-behavioural therapy and maintenance antidepressants. We need to do more research, however, to get recovery rates closer to 100% and to help prevent the first onset of depression, earlier in life. These are programmes of work we are pursuing at the University of Oxford and with our collaborators around the world.'
MBCT is a treatment developed to help people who have experienced repeated bouts of depression by teaching them the skills to recognise and to respond constructively to the thoughts and feelings associated with relapse, thereby preventing a downward spiral into depression. The MBCT course consists of guided mindfulness practices, group discussion and other cognitive behavioural exercises. Participants receiving MBCT typically attended eight 2-2.5 hour group sessions alongside daily home practice.
About the analysis
The nine trials contributing to the current study were conducted in the UK, Belgium, Canada, the Netherlands and Switzerland. The current analysis involved data from 1258 participants from these trials. In all the trials, MBCT was delivered according to the published treatment manual and all trials included people with a history of recurrent depression who were currently in full or partial remission from depression. In each trial, MBCT was compared to either usual care or a non-MBCT approach, typically maintenance anti-depressants. Only one trial compared MBCT to another psychological treatment
An online blog Mindfulness-based cognitive therapy for recurrent depression: What do we know? What does it mean? Where to next? provides more detailed context and interpretation of this study and can be found at http://oxfordmindfulness.org. The blog provides more detail and interpretation of the key studies bearing on the question of MBCT's effectiveness, especially compared with the mainstay current approach - maintenance anti-depressant treatment. For example, another recent trial by Huijbers and colleagues (2016, British Journal of Psychiatry), showed that where all patients receive MBCT alongside antidepressant medication, subsequent tapering of antidepressants increases risk of relapse to depression.
Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse: An Individual Patient Data Meta-analysis from Randomized Trials JAMA Psychiatry. Published online April 27, 2016. doi:10.1001/jamapsychiatry.2016.0076.