Gene linked to risk of common type of stroke | University of Oxford

Gene linked to risk of common type of stroke

A genetic variant that increases the risk of a common type of stroke has been identified by an international group of scientists.

The study, led jointly by researchers at the University of Oxford and St George’s, University of London, discovered one of the few genetic variants to be associated with risk of stroke so far.

The researchers believe their findings, published in the journal Nature Genetics, open up possibilities for developing new treatments.

Stroke is a leading cause of death worldwide, resulting in over 6 million deaths each year, and is a major cause of chronic disability.

One of the most common types of stroke occurs when blood flow is impaired because of a blockage to one or more of the large arteries supplying blood to the brain – large artery ischemic stroke. This accounts for over a third of all strokes.

In one of the largest genetic studies of stroke to date, the international group of scientists from Europe, America and Australia, compared the genetic make-up of 10,000 people who had suffered from a stroke with 40,000 healthy individuals. The study was funded by the Wellcome Trust.

The researchers discovered an alteration in a gene called HDAC9 which affects a person’s risk of large artery ischemic stroke.

This gene variant occurs on about 10 percent of human chromosomes. Those people who carry two copies of the variant (one inherited from each parent) have nearly twice the risk for this type of stroke compared to those with no copies of the variant. 

The protein produced by HDAC9 is already known to play a role in the formation of muscle tissue and heart development. However, the exact mechanism by which the genetic variant increases the risk of stroke is not yet known.

A better understanding of the mechanism could lead to new drugs to treat or prevent stroke. However, the researchers stress that this is still some way off.

The variant does not have the same effect on the risk of other types of stroke which include bleeding in the brain (haemorrhagic stroke).

‘Our study shows that the different subtypes of stroke could involve quite different genetic mechanisms,’ explains Professor Peter Donnelly, director of the Wellcome Trust Centre for Human Genetics at the University of Oxford, who co-led the study.

‘This is really fascinating, and if it holds up more generally, will move us closer to personalised medicine, where treatments and preventions can be tailored more precisely to individual patients.’

Professor Hugh Markus, the other lead researcher from St George’s, University of London, says: ‘This discovery identifies a completely new mechanism for causing stroke. The next step is to determine in more detail the relationship between HDAC9 and stroke and see whether we can develop new treatments that reduce the risk of stroke. Interestingly, there are already drugs available which inhibit the HDAC9 protein. However, it is important that we understand the mechanism involved before trialling the effects of these drugs on stroke.’

Dr Peter Coleman, deputy director of research at the Stroke Association, who funded collection of some of the samples used in the study, said: ‘Over a third of strokes are caused by a blockage in one of the large blood vessels supplying blood to the brain (large artery stroke). Findings from this ground breaking study appear to show a genetic link which may affect a person’s risk of large vessel stroke. Further study is needed, but this research could potentially lead to new methods of screening and prevention for large vessel stroke, and ultimately, new methods of treatment.’