Professor Alex Bullock
Associate Professor, Centre for Medicines Discovery
Professor Alex Bullock's work aims to understand the molecular structure and function of protein kinases and E3 ubiquitin ligases that control cell growth and differentiation and how these might be targeted by small molecule inhibitors to address diseases such as cancer and inflammation.
- Fibrodysplasia ossificans progressiva (FOP), an extremely rare genetic disorder that causes muscles, tendons, ligaments and other connective tissues to turn to bone
- BTB-Kelch family ubiquitin ligases
- ACVR1 protein kinase
- Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva . (Williams et al, 2021. JCI Insight, 6(8):e95042.)
- Targeted protein degradation: expanding the toolbox. (Schapira M. et al, 2019. Nat Rev Drug Discov, 18, 949 - 963)
- ACVR1 mutations in DIPG: lessons learned from FOP (2014)
Professor Alex Bullock has experience working in film, television and radio:
- 2019: featured in the film documentary Tin Soldiers (Blink Pictures) about fibrodyplasia ossificans progressiva (FOP) with an interview and filming around the Old Road Science Campus and labs. The film aimed to find the predicted 3,000 undiagnosed cases of FOP across the world and won awards at numerous international film festivals. It is now used by FOP patient groups worldwide.
- 2015: television interview about his FOP research on the Discovery Channel Network TLC programme Body Bizarre.
- 2012: interviewed live on ITV's This Morning programme alongside a FOP patient who was featured in the Channel 4 documentary The Human Mannequin.
- 2010: live radio interview about FOP on the BBC Oxford primetime Bill Heine Show.