Dr Thomas Lanyon-Hogg
About
Dr Thomas Lanyon-Hogg is a Wellcome Trust Career Development Award Fellow in the Department of Pharmacology at the University of Oxford.
His research in chemical biology involves the use of chemical methodology and small molecules to probe biological questions. This encompasses a range of methodology including organic synthesis, biorthogonal 'click' chemistry and biochemical or mass spectrometry-based proteomic analyses.
Current areas of interest include generation of novel platforms for modulation of protein-protein interactions and profiling of small-molecule targets in vivo.
As part of the Medicinal Chemistry Group in the Department of Pharmacology, his research involves the synthesis and development of biologically active small-molecules. This includes identification of new inhibitors by screening approaches, design of improved molecules using rational and computational guidance, and testing of molecules in biochemical, cellular and in vivo settings.
Current medicinal chemistry projects include: development of molecules to reverse antibiotic resistance; development of inhibitors of the Hedgehog signalling pathway in cancer; identification of modulators of protease activity in cancer and development.
Expertise
- Antibiotics
- Antimicrobial resistance (AMR)
- Drug discovery
- Medicinal chemistry
Selected publications
- Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments (2025)
- Development of an inhibitor of the mutagenic SOS response that suppresses the evolution of quinolone antibiotic resistance (2024)
- Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus (2019)
Media experience
Dr Thomas Lanyon-Hogg has media experience including interviews and blogs and his research has been covered in the press.
Languages
English