"How antibodies fight infection from inside our cells"

Antibodies were once thought to block infection simply by intercepting pathogens outside our cells. Unexpected discoveries have now revealed that antibodies have a second, secret life inside cells. Here, antibodies protect us from viruses, bacteria and pathogenic proteins by targeting them for destruction in the cells own recycling machinery. In my talk, I will discuss our recent work uncovering how this remarkable system of intracellular antibody immunity works and how we are exploiting our understanding to design new therapeutics for the treatment of diverse diseases from infection to neurodegeneration.