From disease genes to mechanisms and therapeutic opportunities

Professor John Todd FRS
Event date
Event time
12:00 - 13:00
Wellcome Trust Centre for Human Genetics
Roosevelt Drive
Venue details

Seminar Rooms A / B

Event type
Lectures and seminars
Disabled access?
Booking required
Not required

Lecture by Professor John Todd, Director, JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research.

Genetics: define the genetic basis of the common autoimmune disease type 1 diabetes by fine-mapping disease-associated causal variants and haplotypes, identify their target genes, and investigate the regulation of these genes before and after cell activation/differentiation.

Phenotypes and mechanisms: identify aberrant cellular interactions and pathways caused by susceptibility genes that mediate a loss of immune tolerance to insulin-producing beta cells culminating in their destruction. These will provide potential targets for therapeutic intervention, as demonstrated by our work in the IL-2 pathway.

Experimental medicine: complete our mechanistic investigations of the effects of IL-2 administration in patients, as a prelude to testing the efficacy of ultra-low dose IL-2 in the preservation of C-peptide and beta-cell function. Investigate using the same mechanistic approach and depending on our emerging knowledge, another potential therapeutic.

Further information is at

The lecture is part of the Wellcome Trust Centre for Human Genetics' high-profile seminar series.