The Nanoimager

A desktop super-resolution microscope

Nanoimager microscope on a lab benchtopNanoimager microscope
The Nanoimager is a highly miniaturised yet extremely powerful high-resolution optical microscope that detects single fluorescent molecules. It has popularised single-molecule imaging and its use in localisation microscopy; this modern methodology relies on high-precision measurements of the location of single fluorescent molecules to break the diffraction limit in optical microscopy by an order of magnitude and deliver much sharper images of living biological cells.

The small size of the Nanoimager and outstanding design make it extraordinarily stable, and allow it to be used on regular laboratory benches, including even office desks, allowing this cutting-edge technology to “escape” from laboratories in Physics departments and reach chemists, biologists, and biomedical scientists who are keen to exploit the use of ultrasensitive detection and super- resolution microscopy.

The microscope reveals the motions, structure, and arrangement of biomolecules and nanoparticles on surfaces, in solutions, and living cells, accelerating academic and industrial research, diagnostics, drug discovery, chemical analysis, and education. 

The Nanoimager was commercialized in 2016 via the Oxford spin-out Oxford Nanoimaging (ONI), which has attracted substantial investment in the past 4 years, has ~100 employees at Oxford and California, and already sold a large number of microscopes worldwide.

Research funded by:  European Research Council and Joint Synthetic Biology Initiative grant (co-funded by EPSRC, BBSRC, MRC and DSTL).