The Genetic Susceptibility to Infection programme in Oxford’s Jenner Institute leads studies aimed at identifying the genes that underlie individual differences in susceptibility to major infectious diseases of the developing world. There have been many links between this group and collaborators in Singapore:
• Chiea Khor, a former DPhil student in the Wellcome Trust Centre for Human Genetics, is currently Senior Research Scientist and Principal Investigator at the Genome Institute of Singapore (GIS.) He is starting his own research laboratory supported by the A*STAR programme. Recent research published by Oxford and his team has identified key genetic variants that increase susceptibility to several infectious diseases – including tuberculosis and malaria. The variations in DNA sequence identified by the scientists occur within a single gene involved in the body’s immune response to infectious disease. This finding could lead the way to greater understanding of the role of this particular gene in disease susceptibility and even to the development of new vaccines.
• Professor Yik Ying Teo, recently of the Wellcome Trust Centre for Human Genetics at Oxford, is now an assistant professor at the National University of Singapore (NUS). Ongoing work with Professor Teo aims to develop better statistical methods to analyse infectious disease susceptibility.
Also working on genetic factors behind disease susceptibility, researchers at the Wellcome Trust Vietnam Research Programme and Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, together with researchers from the Genome Institute of Singapore, have identified two gene variants associated with increased susceptibility to severe dengue. This finding opens up new avenues for understanding and developing a vaccine for the disease. This could go on to have a great impact because dengue is globally the most common mosquito-borne infection after malaria and kills an estimated 100 million people per year.