The Genetic Epidemiology of Psychiatric and Substance Abuse Disorders: Multiple Levels, Interactions and Causal Loops | University of Oxford

The Genetic Epidemiology of Psychiatric and Substance Abuse Disorders: Multiple Levels, Interactions and Causal Loops

Speaker
Kenneth Kendler
Event date
Event time
18:00 - 20:00
Venue
Oxford Martin School
34 Broad Street
Oxford
OX1 3BD
Venue details

Lecture Theatre

Event type
Lectures and seminars
Event cost
Free
Disabled access?
Yes
Booking required
Required

I show how recent studies in the genetic epidemiology and molecular genetics of psychiatric and substance use disorders illustrate the complex causal pathways to mental illness. These include gene-environment interaction in the etiology of major depression (MD) and substance use and abuse, gene-social interactions in drug use, environment-environment interaction in the etiology of MD, and gene-environment covariation in the etiology of MD. I will illustrate the role of genetic factors on the comorbidity of psychiatric disorders using both twin and molecular methods, and describe complex developmental models for MD and alcohol use disorder. I will conclude with a classical example of top-down causation: the impact of human decision-making on the gene-to-phenotype pathway for psychiatric illness.